February 22, 2008 Meeting Joint with IIT The Kilpatrick Lecture & Banquet

Professor Fraser Stoddard a Trustees Professor at Northwestern University, Evanston, IL
" Chemistry and Molecular Nanotechnology in Tomorrow's World "

Date:	February 22, 2008
Location:	IIT’s McCormick Tribune Campus Center Auditorium and Ballroom MTCC 3201 South State St. Chicago, IL

Cost:  $34 for members of ACS and their guests, $36 for non-members,
     $17 for students or unemployed

Dinner reservations are required and should be received in the Section Office via phone (847-647-8405), FAX (847-647-8364), email (chicagoacs@ameritech.net), or web by 8:30 AM on Wednesday, February 20.    PLEASE HONOR YOUR RESERVATIONS.  The Section must pay for all dinner orders.  No-shows will be billed.

  Please REGISTER ON LINE 

5:00 - 6:00  PM Job Club
5:30 - 7:00  PM Social Hour
6:00 - 7:00 Pre-dinner Lecture
7:00  PM Dinner
8:00  PM Program

Abstract: 

Molecular compounds, comprised of mechanically interlocked components, can now be obtained efficiently using template-directed protocols that rely upon supramolecular assistance to covalent synthesis. Since the weak noncovalent interactions that orchestrate the synthesis of such compounds (e.g., catenanes and rotaxanes) containing mechanical bonds live on between the components inside the molecules thereafter, they can be activated such that their components move with respect to each other in either a linear fashion (e.g., the ring component along the rod of the dumbbell component of a rotaxane as in a molecular shuttle) or a rotary manner (e.g., one ring in a [2]catenane circumrotating through the other ring as in a bistable switch). Thus, [2]rotaxanes can be likened to linear motors and [2]catenanes to rotary motors. Moreover, these molecules can be activated by switching the recognition elements on and off between the components chemically, electrically, and optically such that they perform motions (e.g., shuttling actions or muscle-like elongations and contractions) reminiscent of the moving parts in macroscopic machines. Such motor-molecules and molecular machines hold considerable promise for the fabrication of sensors, actuators, amplifiers and switches at the nanoscale level.

Professor Stoddart and his research group work primarily in four different areas, recognizing that chemistry is about three M's - Making, Measuring and Modeling: (1) unnatural product synthesis that is either kinetically or thermodynamically controlled; (2) physical organic chemistry, principally as it relates to chemical topology and supramolecular phenomena; (3) design and construction of artificial molecular machinery, with actuators and switches particularly in mind; (4) the application of nanoscale chemistry to fundamental problems at the interfaces with materials science and the life sciences.

During the past two decades, the Stoddart group has demonstrated how the emergence of the mechanical bond in chemistry has brought with it a real prospect of integrating a bottom-up approach, based on self-assembly and self-organization of motor-molecules, with a top-down approach, based on micro- and nanofabrication, to create nanomechanical systems in order to harness, manipulate and transfer energy on the nanoscale level. It is an approach to nanoscience and nanotechnology that relies fundamentally upon concept transfer from the life sciences into materials science. In the future, Professor Stoddart anticipates (1) the development of new (supra)molecular motors, (2) the designing of methods to induce them to operate coherently and controllably on surfaces and within frameworks as machines and functioning devices, (3) the elaboration of integrated power supplies to drive the machines and devices, (4) an integration of bottom-up and top-down procedures for the nano- and microfabrication of molecularly-driven sensors, actuators, amplifiers and switches, (5) an increased understanding and appreciation of the science and engineering that lies behind nanoscale processes, and (6) the emergence of highly trained scientists and technologists with both broad perspectives and individual expertise in the fields of nanoscience and molecular nanotechnology. All this and more is in the nature of the mechanical bond as it impacts upon chemistry and beyond.

Biography:

Fraser Stoddart received his B.Sc. (1964) and Ph.D. (1966) degrees from Edinburgh University. In 1967, he went to Queen's University (Canada) as a National Research Council Postdoctoral Fellow, and then, in 1970, to Sheffield University as an Imperial Chemical Industries (ICI) Research Fellow, before joining the academic staff as a Lecturer in Chemistry. He was a Science Research Council Senior Visiting Fellow at the University of California, Los Angeles (UCLA) in 1978. After spending a sabbatical (1978-81) at the ICI Corporate Laboratory in Runcorn, he returned to Sheffield where he was promoted to a Readership in 1982. He was awarded a D.Sc. degree by Edinburgh in 1980 for his research into stereochemistry beyond the molecule. In 1990, he took up the Chair of Organic Chemistry at Birmingham University and was Head of the School of Chemistry there (1993-97) before moving to UCLA as the Saul Winstein Professor of Chemistry in 1997. In July 2002, he became the Acting Co-Director of the California NanoSystems Institute (CNSI). On May 1, 2003, he was appointed the Director of the CNSI and assumed the Fred Kavli Chair of NanoSystems Sciences. On January 1, 2008, he became a Trustees Professor at Northwestern University.

Stoddart is one of the few chemists of the past quarter of a century to have created a new field of organic chemistry - namely, one in which the mechanical bond is a pre-eminent feature of molecular compounds. He has pioneered the development of the use of molecular recognition and self-assembly processes in template-directed protocols for the syntheses of two-state mechanically interlocked compounds (bistable catenanes and rotaxanes) that have been employed as molecular switches and as motor-molecules in the fabrication of nanoelectronic devices and NanoElectroMechanical Systems (NEMS).

His work has been recognized by many awards, including the Carbohydrate Chemistry Award of The Chemical Society (1978), the International Izatt-Christensen Award in Macrocyclic Chemistry (1993), the American Chemical Society's Cope Scholar Award (1999), and the Nagoya Gold Medal in Organic Chemistry (2004). He was one of approximately 20 research scientists to be invited by the Royal Swedish Academy of Sciences to participate in the Nobel Jubilee Symposium on "Frontiers of Molecular Sciences" in Stockholm in December 2001. In 2005, he received the Honorary Degree of Doctor of Science from Birmingham University, as well as being the recipient of the University of Edinburgh Alumnus of the Year 2005 Award. In late 2006, he will receive an Honorary Degree of Doctor of Science from the University of Twente. He is currently on the international advisory boards of numerous journals, including Angewandte Chemie and the Journal of Organic Chemistry. He is the editor of the Royal Society of Chemistry Series of Monographs on Supramolecular Chemistry. He is a Fellow of the Royal Society (1994), the German Academy of Natural Sciences (1999), the American Association for the Advancement of Science (2005), and the Science Division of the Royal Netherlands Academy of Arts and Sciences (2006).

In addition to being made an Honorary Professor at the East China University of Science and Technology in Shanghai and the Carnegie Centenary Visiting Professor at the Scottish Universities in 2005, Stoddart has been awarded named lectureships by more than 40 universities. He went on Royal Society Lecture Tours of the USSR and Japan in 1986 and 1987, respectively, and has been knighted by Queen Elizabeth.

Some measure of the influence and impact of Stoddart's work may be drawn from citation statistics. Four of his more than 790 publications have been cited over 500 times, 11 over 300, 54 over 100, and 155 over 50. For the period from January 1997 to February 28, 2007, he is ranked by the Institute for Scientific Information as the third most cited chemist with a total of 12,840 citations from 293 papers at a frequency of 43.8 citations per paper. He has given almost 700 plenary/invited lectures. During 37 years, over 280 PhD and postdoctoral students have passed through his laboratories and been inspired by his imagination and creativity, and more than 60 have subsequently embarked upon successful independent academic careers.

Predinner Lecture:

"Highly Efficient Syntheses of Mechanically Interlocked Molecules"

Dr. William R. Dichtel,
Research Associate, Northwestern University, Evanston, IL

Abstract: The mechanical bonds and noncovalent forces contained within mechanically interlocked molecules give rise to relative motions, such as circumrotation and shuttling, that have been utilized in artificial molecular muscles and molecular electronic devices. Mechanically interlocked molecular compounds based on donor-acceptor interactions, incorporating cyclobis(paraquat-p-phenylene) (CBPQT⁴⁺) as the pi-electron accepting ring component, have been synthesized traditionally by template-directed, kinetically controlled reactions in which the partially formed ring is "clipped" around a dumbbell or macrocycle which contains complementary recognition units. Although this clipping approach has been used extensively, the moderate yields associated with the protocol limit its practical utility mostly to the preparation of [2]rotaxanes and [2]catenanes. We have recently harnessed the mild conditions, excellent functional group tolerance, and high efficiency of the Cu(I)-catalyzed azide - alkyne cycloaddition for the preparation of a variety of previously inaccessible donor-acceptor rotaxanes and catenanes. The scope of this methodology is far-reaching, allowing for the synthesis of higher order rotaxanes, catenanes, polyrotaxanes, bistable [2]rotaxanes, and liquid crystalline materials.

Speaker's Biography: William Dichtel was born in Houston, Texas, in 1978 and grew up in Roanoke, Virginia. He received his B.S. in chemistry in 2000 from the Massachusetts Institute of Technology and his Ph.D. in 2005 from the University of California, Berkeley under the supervision of Prof. Jean M. J. Fréchet. He is a research associate working jointly with Prof. J. Fraser Stoddart. His research interests include molecular electronics, novel macromolecular architectures and functional materials.

Map and Directions

Parking:   The closest parking lots are the Visitor's Parking Lot A4 immediately north of the MTCC and Lot D1 immediately south (across 33rd street) of the MTCC. Parking is free after 7 p.m. in Lots A4 and D1. Before 7 p.m., parking is metered. Visit parking.iit.edu or map for maps and more parking info.

There is free street parking on both sides of 30th street (for a block west from State Street) and on State street north of 30th and south of 35th street with rush hour restrictions on the west side (for south bound traffic from 4:30 to 6:30 p.m.)

Pear and roasted walnut spring salad.
 
Entree choices
1) Beef tenderloin tips in a burgundy wine sauce.
2) Fresh atlantic salmon with coconut curry sauce.
3) Roasted vegetable lasagna.
 
Side dishes are risotto with mushrooms and fresh steamed broccoli spears.
 
Bread pudding desert